@conference {968, title = {Long-term grey matter structural changes in the transition from chronic migraine to episodic migraine}, booktitle = {8th Congress of the European Academy of Neurology}, year = {2022}, month = {2022}, abstract = {

Background and aims: The objective was to assess grey matter longitudinal changes in patients with chronic migraine (CM) who reverse to episodic migraine (EM) compared to those who do not reverse.

Methods: High-resolution 3D brain T1-weighted Magnetic Resonance Imaging data were obtained twice from migraine patients. The first acquisition was performed immediately after the first visit to the Headache Unit, before taking preventive treatments. The second timepoint was at least three years after the first acquisition. From the longitudinal pipeline of FreeSurfer (v6.0), the mean values of cortical thickness, surface area and grey matter volume of 68 cortical, 14 subcortical regions and the cerebellum were extracted. Longitudinal changes between patients with CM and those who reversed to EM were assessed with linear
mixed-effects models, setting p\<0.05 (false discovery rate corrected) as threshold for statistical significance.

Results: 22 patients were included, and 10 of them (45.5\%) reversed to EM. No statistically significant differences of age (42.0+-9.0 years) and sex (21 women, 95.5\%) were found between patient groups. Higher statistically significant values of the three parameters in patients who reversed to EM were found in the pericalcarine, parietal, orbitofrontal cortex, and amygdala (Table 1, Figure 1). In contrast, lower values were detected in the cingulum, caudal middle frontal cortex, cerebellum, caudate nucleus and pallidum (Figure 2). In the insula, higher thickness but lower area was appreciated in patients who reversed.

Conclusion: Patients with CM who reverse to EM present distinct patterns of increased and decreased morphometric parameters propagated in the orbital frontal cortex and the cingulum, respectively.

Disclosure: Nothing to disclose.

}, author = {{\'A}lvaro Planchuelo-G{\'o}mez and Marchante-Re{\'\i}llo, Ginebra and Sierra, {\'A}lvaro and Garc{\'\i}a-Azor{\'\i}n, David and Mart{\'\i}n-Mart{\'\i}n, Carmen and de Luis-Garc{\'\i}a, Rodrigo and Aja-Fern{\'a}ndez, Santiago and Moro, Ra{\'u}l and Rodr{\'\i}guez, Margarita and Gonz{\'a}lez-Osorio, Y{\'e}sica and {\'A}ngel L. Guerrero} } @conference {945, title = {Longitudinal reduction of quality of life in patients with epilepsy and no seizure increase during the COVID-19 pandemic}, booktitle = {7th Congress of the European Academy of Neurology}, year = {2021}, month = {2021}, publisher = {Wiley}, organization = {Wiley}, address = {Virtual Congress}, abstract = {

Background and aims: In early 2020, the novel coronavirus disease (COVID-19) pandemic has impaired medical care of chronic neurological diseases, including epilepsy. The objective of this study is to evaluate the impact of the COVID-19 pandemic in the levels of anxiety, depression, somnolence and quality of life using validated scales in patients with epilepsy in real-life clinical practice.
Methods: Self-administered scales of anxiety disorders (GAD-7), depression (NDDI-E), somnolence (Epworth Sleepiness Scale; ESS) and quality of life (QOLIE-31-P) in patients with epilepsy treated in the Refractory Epilepsy Unit of a tertiary hospital were longitudinally analyzed with Generalized Linear Mixed Models. Data were collected before the beginning (December 2019-March 2020) and during the COVID-19 pandemic (September 2020-January 2021).
Results: 37 patients, 45.0+-17.3 years of age, 43.2\% women, epilepsy duration 23.0+-14.9 years, number of anti-epileptic drugs 2.1+-1.4, answered in the two periods. Significant longitudinal reduction of QOLIE-31-P scores (from 58.9+-19.7 to 56.2+-16.2, p=0.035) was identified. No statistically significant longitudinal changes in NDDI-E (from 12.3+-4.3 to 13.4+-4.4, p=0.293) or the number of seizures (from 0.9+-1.9 to 2.5+-6.2, p=0.125) were found. Significant higher ESS (from 4.9+-3.7 to 7.4+-4.9, p=0.001) and lower GAD-7 scores (from 8.8+-6.2 to 8.3+-5.9, corrected p=0.024 adjusted by refractory epilepsy and sleep disturbance) were found during the COVID-19 pandemic.
Conclusion: During the COVID-19 pandemic, quality of life was lower in patients with epilepsy, levels of anxiety were reduced and sleepiness levels were raised, without seizure change. Additional studies would be useful to adequately manage these comorbidities.
Disclosure: There is no disclosure.

}, url = {https://www.ean.org/fileadmin/user_upload/ean/congress-2021/EAN2021AbstractBook.pdf}, author = {Gonzalez-Martinez, Alicia and {\'A}lvaro Planchuelo-G{\'o}mez and Vieira, Alba and Mart{\'\i}nez-Dubarbie, Francisco and Vivancos, Jos{\'e} and De Toledo, Mar{\'\i}a} } @article {890, title = {Longitudinal evaluation of the psychological impact of the COVID-19 crisis in Spain}, journal = {Journal of Affective Disorders}, volume = {277}, year = {2020}, pages = {842-849}, abstract = {Background: Strict confinement and social distancing measures have been imposed due to the COVID-19 pandemic in many countries. The aim was to assess the temporal evolution of the psychological impact of the COVID-19 crisis and lockdown from two surveys, separated by one month, performed in Spain. Methods: Symptoms of depression, anxiety and stress, and the psychological impact of the situation were longitudinally analyzed using the Depression Anxiety and Stress Scale (DASS-21) and the Impact of Event Scale (IES) respectively. Results: There was a total of 4,724 responses from both surveys. Symptomatic scores of anxiety, depression and stress were exhibited by 37.22\%, 46.42\% and 49.66\% of the second survey respondents, showing a significant increase compared to the first survey (32.45\%, 44.11\% and 37.01\%, respectively). There was no significant longitudinal change of the IES scores, with 48.30\% of the second survey participants showing moderate to severe impact of the confinement. Constant news consumption about COVID-19 was found to be positively associated with symptomatic scores in the different scales, and daily physical activity to be negatively associated with DASS-21 scores. Conclusions: Results indicated a temporal increase of anxiety, depression and stress scores during the COVID-19 lockdown. Factors such as age, consumption of information about COVID-19 and physical activity seem to have an important impact on the evolution of psychological symptoms.}, keywords = {Anxiety, COVID-19, Depression, Longitudinal study, Post-traumatic, Psychological, Stress, Stress disorders}, issn = {0165-0327}, doi = {10.1016/j.jad.2020.09.018}, url = {http://www.sciencedirect.com/science/article/pii/S0165032720327130}, author = {{\'A}lvaro Planchuelo-G{\'o}mez and Odriozola-Gonz{\'a}lez, Paula and Irurtia, Mar{\'\i}a Jes{\'u}s and Rodrigo de Luis-Garc{\'\i}a} }