@article {943, title = {Medium-term changes in patients with epilepsy during the COVID-19 pandemic}, journal = {Acta Neurologica Scandinavica}, volume = {144}, year = {2021}, pages = {450-459}, abstract = {

Objectives: The novel coronavirus disease (COVID-19) pandemic has led to social distancing measures and impaired medical care of chronic neurological diseases, including epilepsy, which may have adversely affected well-being and quality of life of patients with epilepsy (PWE). The objective of this study is to evaluate the impact of the COVID-19 pandemic in the levels of anxiety, depression, somnolence, and quality of life using validated scales in PWE in real-life clinical practice.

Materials \& Methods: Self-administered scales of anxiety disorders (GAD-7), depression (NDDI-E), somnolence (Epworth Sleepiness Scale; ESS), and quality of life (QOLIE-31-P) in PWE treated in a Refractory Epilepsy Unit were longitudinally analyzed. Data were collected before the beginning (December 2019-March 2020) and during the COVID-19 pandemic (September 2020-January 2021).

Results: 158 patients (85 from the first round and 73 from the second round) 45.0 +- 17.3 years of age, 43.2\% women, epilepsy duration 23.0 +- 14.9 years, number of antiepileptic drugs 2.1 +- 1.4, completed the survey. Significant longitudinal reduction of QOLIE-31-P (from 58.9 +- 19.7 to 56.2 +- 16.2, p = 0.035) and GAD-7 scores (from 8.8 +- 6.2 to 8.3 +- 5.9, corrected p = .024) was identified. No statistically significant longitudinal changes in the number of seizures (from 0.9 +- 1.9 to 2.5 +- 6.2, p = .125) or NDDI-E scores (from 12.3 +- 4.3 to 13.4 +- 4.4, p = .065) were found. Significant longitudinal increase of ESS (from 4.9 +- 3.7 to 7.4 +- 4.9, p = .001) was found.

Conclusions: During the COVID-19 pandemic, quality of life and anxiety levels were lower in PWE, and sleepiness levels were raised, without seizure change.

}, keywords = {Anxiety, COVID-19, Sleep, epilepsy, pandemic, quality of life}, doi = {https://doi.org/10.1111/ane.13481}, url = {https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.13481}, author = {Gonzalez-Martinez, Alicia and {\'A}lvaro Planchuelo-G{\'o}mez and Vieira Campos, Alba and Mart{\'\i}nez-Dubarbie, Francisco and Vivancos, Jos{\'e} and De Toledo-Heras, Mar{\'\i}a} } @proceedings {576, title = {Automatic diagnosis of ADHD based on nonlinear analysis of actimetry registries}, volume = {32}, year = {2011}, pages = {685-688}, address = {Prague, Czech Rep.}, keywords = {ADHD, ADHD automatic diagnosis, Activity/Rest Detection, Attention-Deficit Hyperactivity Disorder, Automatic Diagnosis System, Central Tendency Measure, Feature extraction, Histograms, Indexes, Noise, Pediatrics, Regularity Assessment, Sleep, USA Councils, Wrist, actimetry registries, adolescence, automatic activity/rest detection filter, biomedical measurement, childhood, feature extraction module, medical disorders, medical signal processing, mental health problem, neurophysiology, nonlinear analysis, nonlinear regularity quantification, paediatrics, pathology, signal processing methods}, author = {Diego Mart{\'\i}n-Mart{\'\i}nez and Pablo Casaseca-de-la-Higuera and Susana Alberola-Lopez and L{\'o}pez-Villalobos, J.A. and Ruiz, F.C. and Jesus Maria Andres-de-Llano and Jose Ramon Garmendia-Leiza and Julio Ardura-Fernández} }