Optimal design of motion-compensated diffusion gradient waveforms

TitleOptimal design of motion-compensated diffusion gradient waveforms
Publication TypeConference Proceedings
Year of Conference2017
AuthorsPeña-Nogales, Ó., R. de Luis-García, S. Aja-Fernández, Y. Zhang, J. H. Holmes, and D. Hernando
Conference NameInternational Society of Magnetic Resonance in Medicine 25th Annual Meeting and Exhibition
Conference LocationHonolulu, HI, USA

Diffusion-Weighted MRI (DW-MRI) often suffers from motion-related artifacts in organs that experience physiological motion. Importantly, organ motion during the application of diffusion gradients results in signal losses, which complicate image interpretation and bias quantitative measures. Motion-compensated gradient designs have been proposed, however they typically result in substantially lower b-values or severe concomitant gradient effects. In this work, we develop an approach for design of first- and second-order motion-compensated gradient waveforms based on a b-value maximization formulation including concomitant gradient nulling, and we compare it to existing techniques. The proposed design provides optimized b-values with motion compensation and concomitant gradient nulling.